Multiparametric Identification of Putative Senescent Cells in Skeletal Muscle via Mass Cytometry

Yijia Li, Nameera Baig, Daniel Roncancio, Kris Elbein, Dawn Lowe, Michael Kyba, Edgar A. Arriaga *

(2024) Cytometry Part A

Electrophoresis - 2023 - Koh.pdf

Numerical modeling reveals improved organelle separation for dielectrophoretic ratchet migration

Domin Koh, Mukul Sonker, Edgar A. Arriaga , Alexandra Ros

(2023) Electrophoresis

CosTaL: an accurate and scalable graph-based clustering algorithm for high-dimensional single-cell data analysis

Yijia Li, Jonathan Nguyen, David C Anastasiu, Edgar A Arriaga *

(2023) Briefings in Bioinformatics


Combining Isoprenoid Probes with Antibody Markers for Mass Cytometric Analysis of Prenylation in Single Cells

Zoë A. Maxwell , Kiall F. Suazo, Heather M.G. Brown, Mark D. Distefano, and Edgar A. Arriaga*

(2022) Analytical Chemistry

Electrophoresis - 2022 - Ortiz - Continuous organelle separation in an insulator‐based dielectrophoretic device (2).pdf

Continuous organelle separation in an insulator-based dielectrophoretic device

Ricardo Ortiz, Domin Koh, Dai Hyun Kim, Mohammad Towshif Rabbani, Cesar Anguaya Velasquez, Mukul Sonker, Edgar A. Arriaga, Alexandra Ros* 

(2022) Electrophoresis 

Metallointercalators-DNA Tetrahedron Supramolecular Self-Assemblies with Increased Serum Stability

M. Andrey Joaqui-Joaqui, Zoe Maxwell, Mandapati V. Ramakrishnam Raju, Min Jiang, Kriti Srivastava, Fangwei Shao, Edgar A. Arriaga, and Valérie C. Pierre* 

(2022) ACS Nano


Introducing the Journal of Chemical Education’s Special Issue on Diversity, Equity, Inclusion, and Respect in Chemistry Education Research and Practice

Zakiya S. Wilson-Kennedy, Leyte L. Winfield*, Jennifer Nielson, Edgar A. Arriaga, Ann C. Kimble-Hill, and Florastina Payton-Stewart

(2022) Journal of Chemical Education


Guidelines for Advancing Diversity, Equity, Inclusion, and Respect in Programs Offering Bachelor’s Degrees in Chemistry

Michelle M. Brooks*, Felicia A. Fullilove, Ashley B. Mahoney, and Edgar A. Arriaga*

(2022) Journal of Chemical Education



Journal of Chemical Education Call for Papers: Special Issue on Diversity, Equity, Inclusion, and Respect in Chemistry Education Research and Practice 

Leyte L. Winfield,* Zakiya S. Wilson-Kennedy, Florastina Payton-Stewart, Jennifer Nielson, Ann C. Kimble-Hill, and Edgar A. Arriaga.

(2021) Journal of Chemical Education

2015 - 2020

Nonspecific Binding Correction for Single-Cell Mass Cytometric Analysis of Autophagy and Myblast Differentiation 

Heather M. G. Brown, Michelle M. Kuhns, Zoe Maxwell, and Edgar A. Arriaga*

(2020) Analytical Chemistry

Quantifying Heterogeneity of Individual Organelles in Mixed Populations via Mass Cytometry

Heather M. G. Brown and Edgar A. Arriaga*

(2018) Analytical Chemistry

Deterministic Ratchet for Sub-micrometer (Bio)particle Separation

Daihyun Kim, Jinghui Luo, Edgar A. Arriaga, and Alexandra Ros*

(2018) Analytical Chemistry


Development of a Click-Chemistry Reagent Compatible with Mass Cytometry

Jessica Shaklee, Kriti Srivastava, Heather Brown, Edgar A. Arriaga, Valerie C. Pierre, and Jop H. van Berlo*

(2018) Scientific Report


Fisetin is a senotherapeutic that extends health and lifespan

Matthew J. Yousefzadeh, Yi Zhu, Sara J. McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I. Melos, Tamar Pirtskhalava, Christina L. Inman, Collin McGuckian, Erin A. Wade, Jonathon I. Kato, Diego Grassi, Mark Wentworth, Christin E. Burd, Edgar A. Arriaga, Warren L. Ladiges, Tamara Tchkonia, James L. Kirkland, Paul D. Robbins*, and Laura J. Niedernhofer *

(2018) EBioMedicine

Sizing lipid droplets from adult and geriatric mouse liver tissue via nanoparticle tracking analysis

Katherine A. Muratore, Charles P. Najt, Nicholas M. Livezey, James Marti, Douglas G. Mashek, and Edgar A. Arriaga*

(2018) Analytical and Bioanalytical Chemistry

Checkpoints for preliminary identification of small molecules found enriched in autophagosomes and activated mast cell secretions analyzed by comparative UPLC/MSe

Chad P. Satori, Marzieh Ramezani, Joseph S. Koopmeiners, Audrey F. Meyer, Jose A. Rodriguez-Navarro, Michelle M. Kuhns, Thane H. Taylor, Christy L. Haynes, Joseph J. Dalluge and Edgar A. Arriaga*

(2017) Analytical Methods

Metabolic Labeling with an Alkyne-modified Isoprenoid Analog Facilitates Imaging and Quantification of the Prenylome in Cells

Charuta C. Palsuledesai, Joshua D. Ochocki, Michelle M.  Kuhns, Yen-Chih Wang, Janel K. Warmka, Dustin S. Chernick, Elizabeth V. Wattenberg, Ling Li, Edgar A. Arriaga, and Mark  D. Distefano*

(2016) ACS Chemical Biology

Capillary Electrophoresis with Laser-Induced Fluorescent Detection of Immunolabeled Individual Autophagy Organelles Isolated from Liver Tissue

Katherine A. Muratore, Heather M. Grundhofer, and Edgar A. Arriaga*

(2016) Analytical Chemistry

Identification and Characterization of Mitochondrial Subtypes in Caenorhabditis elegans via Analysis of Individual Mitochondria by Flow Cytometry

Joseph R. Daniele, Kartoosh Heydari, Edgar A. Arriaga*, and Andrew Dillin

(2016) Analytical Chemistry

Deterministic Absolute Negative Mobility for Micro- and Submicrometer Particles Induced in a Microfluidic Device

Jinghui Luo, Katherine A. Muratore, Edgar A. Arriaga, and Alexandra Ros*

(2016) Analytical Chemistry

Nanohole Array-Directed Trapping of Mammalian Mitochondria Enabling Single Organelle Analysis

Shailabh Kumar, Gregory G. Wolken, Nathan J. Wittenberg, Edgar A. Arriaga*, and Sang-Hyun Oh*

(2015) Analytical Chemistry

Older Publications

122. Simultaneous Measurement of Individual Mitochondrial Membrane Potential and Electrophoretic Mobility by Capillary Electrophoresis Wolken, G.G.; Arriaga, E.A., Anal. Chem. 86(9), 4217-26 (2014). (PMC4018156). DOI 

121. Pro-inflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress and dynamics Hahn W.S; Kuzmicic, J.; Burrill, J.B.; Donoghue, M.A.; Jensen, M.D.; Lavandero, S.; Arriaga; E.A.; Bernlohr, D.A, Am. J. Physiol. Endocrinology and Metabolism, 306(9), E1033-45 (2014). (PMC in process). DOI 

120. Insulator-based dielectrophoresis of mitochondria Luo, J.; Abdallah, B.G.; Wolken, G.G.; Arriaga, E.A.; Ros, A., Biomicrofluidics, 8(2), 021801 (2014). (PMC4056684). DOI 

119.   Satori, C. P.; Meyer, B.; Arriaga, E. A. “Monitoring Subcellular Biotransformation of N-L-Leucyldoxorubicin by Micellar Electrokinetic Capillary Chromatography Coupled to Laser Induced Fluorescence Detection”, Anal. Bioanal. Chem. 406(9-10), 2389-97 (2014). (PMID: 24573576).

118.   Taylor, T. H.; Frost, N. W.; Bowser, M. T.; Arriaga, E. A. “Analysis of Individual Mitochondrion via Fluorescent Immunolabeling with Anti-TOM 22 Antibodies”, Anal. Bioanal. Chem., 406(6), 1683-91 (2014). (PMC4332841)

117.   Ro, S.-H.; Jung, C.H.; Hahn, W.S.; Xu, X.; Kim, Y.-M.; Yun, Y.S.; Park, J.-M.; Kim, K.H.; Seo, M.; Ha, T.-Y.; Arriaga, E.A; Bernlohr, D.A.; Kim, D.-H. “Distinct functions of ULK1 and ULK2 in the regulation of lipid metabolism in adipocytes”, Autophagy 9(12), 2103-14 (2013). (PMC in Process)

116.   Satori, C.P.; Arriaga, E.A. “Describing Autophagy via Analysis of Individual Organelles by Capillary Electrophoresis with Laser Induced Fluorescence Detection”, Anal. Chem. 85(23), 11391-400 (2013), (PMC3184341)

115.   Satori, C. P.; Henderson, M. M.; Krautkramer, E. A.; Kostal, V.; Distefano, M. D.; Arriaga, E. A. “Bioanalysis of eukaryotic organelles”, Chemical Reviews, 113(4), 2733-811 (2013). (PMC3676536)

114.   Donoghue, M.A.; Xu, X.; Bernlohr, D.A.; Arriaga, E.A. “Capillary electrophoretic analysis of hydroxyl radicals produced by respiring mitochondria”, Anal. Bioanal. Chem., 405(18), 6053-60 (2013). (PMC3696420)

113.   Wolken, G. G.; Fossen, B. J.; Noh, A.; Arriaga, E. A. “Predicting Isoelectric Points of Non-functional Mitochondria from Monte Carlo Simulations of Surface Compositions”, Langmuir, 29, 2700-7 (2013). (PMC3582746)

112.   Satori, C.P.; Kostal, V.; Arriaga, E.A. "Review on Recent Advances in the Analysis of Isolated Organelles", Anal. Chim. Acta, 753, 8-18 (2012). (PMC3484375)

111.   Curtis, J.M.; Hahn, W.S.; Stone, M.D.; Inda, J.J.; Droullard, D.J.; Kuzmicic, J.P.; Donoghue, M.A.; Long, E.K.; Armien, A.G.; Lavandero, S.; Arriaga, E.A.; Griffin, T.G.; Bernlohr, D.A., "Protein carbonylation and adipocyte mitochondria function", Journal of Biological Chemistry, 287, 32967-80 (2012) (PMC3463318)

110.   Curtis, J.M.; Hahn, W.S.; Long, E.K.; Burril, J.; Arriaga, E.A.; Bernlohr, D.A. “Protein Carbonylation and metabolic Control Systems”, Trends in Endocrinology and Metabolism, 23, 399-406 (2012). (PMC3408802).

109.   Jagtap, P;  Bandhakavi, R.; Higgins, L.; McGowan, T.; Sa, R.; Stone, M.D.; Chilton, J.; Arriaga, E.A.; Seymour, S.L.; Griffin, J.T. “Workflow for analysis of high mass accuracy salivary dataset using MaxQuant and ProteinPilot search algorithm”, Proteomics, 12, 1726-1730 (2012). (PMID: 22623410)

108.   Cabrera, J. A.; Ziemba, E. A., Kelly, R. F.; Sikora, J.; Colbert, R.; Kuskowski, M.; Arriaga, E. A.; Sluiter, W.; Duncker, D. J.; Ward, H. B.; McFalls, E. O. “Uncoupling Protein-2 Expression and Effects on Mitochondrial Membrane Potential and Oxidant Stress in Heart Tissue”, Translational Research, 159, 383-90 (2012). (PMC3328031)

107.   Wang, Y.; Taylor, H.T.; Arriaga, E.A. “Analysis of the Bioactivity of Magnetically Immunoisolated Peroxisomes”, Anal. Bioanal. Chem. 402(1), 41-9 (2012). (Paper at the Forefront) (PMC3251717)

106.   Satori, C. P.; Kostal, V.; Arriaga, E.A. “Individual organelle pH determinations of magnetically-enriched endocytic organelles via laser-induced fluorescence detection”, Anal. Chem. 83 (19), 7331-9 (2011). (PMC3184341)

105.   Wang, Y.; Katzenmeyer, J.B.; Arriaga, E.A. “Combination of Micellar electrokinetic and high-performance liquid chromatographies to assess age-related changes in the in vitro metabolism of Fischer 344 rat liver”, J. Gerontol.: Biol. Sci. 66 (9), 935-43 (2011).

104.   Kostal, V.; Levar, K.; Swift, M.; Skillrud, E.; Chapman, M.; Thompson, L.V.; Arriaga, E.A. “Semi-automated image analysis: Detecting carbonylation in subcellular regions of skeletal muscle”, Anal. Bioanal. Chem. 400, 213-222 (2011). (PMC3066023)

103.   Kostal, V.; Arriaga, E. A. “"Capillary electrophoretic analysis reveals subcellular binding between individual mitochondria and cytoskeleton", Anal. Chem. 83 (5), 1822 – 1829 (2011).

102.   Wolken, G.G.; Kostal, V.; Arriaga, E.A. “Capillary Isoelectric Focusing of Individual Mitochondria", Anal. Chem., 83 (2), 612-618 (2011). (PMC3021621)

101.   Xu, X.; Chen, C-n.; Arriaga, E.A.; Thompson, L.V. “Asymmetric superoxide release inside and outside the mitochondria in skeletal muscle under conditions of aging and disuse”, Journal of Applied Physiology. 109, 1133-1139 (2010).

100.   Katzenmeyer, J.B.; Eddy, C.V.; Arriaga, E.A. “Tandem Laser-Induced Fluorescence and Mass Spectrometry Detection for High-Performance Liquid Chromatography Analysis of the in Vitro Metabolism of Doxorubicin”, Anal. Chem., 82, 8113-8120 (2010). (PMC2989425)

99.  Xu, X.; Arriaga, E.A. “Quantitative Chemical Cytometry Determines the Superoxide Levels in the Mitochondrial Matrix of Single Myoblasts”, Anal. Chem. 82, 6745-6750 (2010).

98.  Xu, X.; Thompson, L.V.; Navratil, M., Arriaga E.A. “Analysis of Superoxide Production in Single Skeletal Muscle Fibers”, Anal. Chem. 82, 4570-4576 (2010).

97.  Poe III, B.G.; Duffy, C.F.; Greminger, M.A.; Nelson, B.J.; Arriaga, E.A. “Detection of Heteroplasmy in Individual Mitochondrial Particles”, Anal. Bioanal. Chem. 397, 3397–3407 (2010). (PMC3035356)

96.  Curtis, J.M.; Grimsrud, P.A.; Wright, W.S.; Xu, X.; Foncea, R.E.; Graham, D.W.; Brestoff, J.R.; Wiczer, B.M.; Ilkayeva, O.; Cianflone, K.; Muoio, D.E.; Arriaga, E.A.; Bernlohr, D.A.  "Down Regulation of Adipose Glutathione S-Transferase Leads to Increased Protein Carbonylation, Oxidative Stress and Mitochondrial Dysfunction", Diabetes 59,1132-1142 (2010). (PMC2857893)

95.  Terman, A.; Brunk, U.; Kurz, T.; Arriaga, E.A.; Narvratil, M. “Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells. The Mitochondrial-Lysosomal Axis Theory of Aging”, Invited Review, Antioxidants and Redox Signaling 12, 503-35 (2010). (PMID1965071)

94.  Davis, J.M; Arriaga, E. A. "Estimation of Migration-time and Mobility Distributions in Organelle Capillary Electrophoresis with Statistical-Overlap Theory”, Anal. Chem. 82, 307–315 (2010). (PMC2803746)

93.  Kostal, V.; Fonslow, B.; Arriaga, E.A.; Bowser, M.T. "Fast Determination of Mitochondria Electrophoretic Mobility Using Micro-Free Flow Electrophoresis", Anal. Chem. 80, 3182-3189 (2009).

92.  Davis, J.M; Arriaga, E. A. "Evaluation of Peak Overlap in Migration-Time Distributions Determined by   Organelle Capillary Electrophoresis: Type-II Error Analogy Based on Statistical-Overlap Theory”, J. Chrom. A, 6335-6342 (2009). (PMC2779522)

91.  Xu, X.; Arriaga, E.A. “Qualitative Determination of Superoxide Release at Both Sides of the Mitochondrial Inner Membrane by Capillary Electrophoretic Analysis of the Oxidation Products of Triphenylphosphonium Hydroethidine”, Free Radical Biol. Med. 46, 905-13 (2009).

90.  Wang, Y.; Hong, J.; Cressman, E.N.K.; Arriaga, E.A. “Direct Sampling from Human Liver Tissue Cross-sections for Electrophoretic Analysis of Doxorubicin” Anal. Chem. 81, 3321-8 (2009). (PMC2675659)

89.  Arriaga, E.A. “Determining Biological Noise Via Single Cell Analysis,” Invited Review, Anal. Bioanal. Chem. 393, 73-80 (2009). (PMC3035192)

88.  Feng, J.; Navratil, M.; Thompson, L.V.; Arriaga, E.A. “Principal Component Analysis Reveals Age-Related and Muscle-Type-Related Differences in Protein Carbonyl Profiles of Muscle Mitochondria”, J. Gerontol.: Biol. Sci. 63A, 1277-88 (2008). (PMC3038117)

87.  Feng, J.; Xie, H.; Meany, D.L; Thompson, L.V.; Arriaga, E.A.; Griffin, T.J. “Quantitative Proteomic Profiling of Muscle-Dependent and Age-Dependent Protein Carbonylation in Rat Skeletal Muscle Mitochondria”, J. Gerontol.: Biol. Sci. 63A, 1137-52 (2008).

86.  Feng, J.; Navratil, M.; Thompson, L.V.; Arriaga, E.A. “Estimating Relative Carbonyl Levels in Muscle Microstructures by Fluorescence Imaging”, Anal. Bioanal. Chem. 391, 2591-8 (2008).

85.  Kostal, V.; Katzenmeyer, J. B.; Arriaga, E.A. “Capillary Electrophoresis in Bioanalysis”, (Invited Review) Anal. Chem. 80, 4533-50 (2008).

84.  Kostal, V.; Arriaga, E.A. “Recent Advances in the Analysis of Biological Particles by Capillary Electrophoresis”, Review, Electrophoresis 29, 2578-86 (2008).

83.  Wang, Y; Arriaga, E.A. “Monitoring Incorporation, Transformation and Subcellular Distribution of N-L-leucyl-doxorubicin in Uterine Sarcoma Cells Using Capillary Electrophoretic Techniques”, Cancer Lett. (Shannon, Irel.) 262, 123-32 (2008).

82.  Whiting, C.E.; Dua, R.; Duffy, C.F; Arriaga, E.A. “The Statistical Limitations of Sampling Individual Particles on Microfluidic Devices with Orthogonal Laser Induced Fluorescence Detection”, Electrophoresis 29, 1431-40 (2008).

81.  Feng, J.; Arriaga, E.A. “Quantification of Carbonylated Proteins in Rat Skeletal Muscle Mitochondria Using Capillary Sieving Electrophoresis with Laser-Induced Fluorescence Detection”, Electrophoresis 29, 475-82 (2008).

80.  Navratil, M.; Terman, A.; Arriaga, E.A.  “Giant Mitochondria Do Not Fuse and Exchange Their Contents with Normal Mitochondria”, Exp. Cell Res. 314, 164-72 (2008).

79.  Navratil, M.; Poe, B.G.; Arriaga, E.A. “Quantitation of DNA Copy Number in Individual Mitochondrial Particles by Capillary Electrophoresis,” Anal. Chem. 79, 7691-9 (2007).

78.  Andreyev, D.S.; Arriaga, E.A. “Fabrication of Perforated Sub-Micron Silica Shells”, Scri. Mater. 57, 957-9 (2007).

77.  Chen, Y.; Arriaga, E.A. “Individual Electrophoretic Mobilities of Liposomes and Acidic Organelles Displaying pH Gradients Across Their Membranes,” Langmuir 23, 5584-90 (2007).

76.  Chen, Y.; Xiong, G.; Arriaga, E. “CE Analysis of the Acidic Organelles of a Single Cell”, Electrophoresis 28, 2406-15 (2007).

75.  Andreyev, D.; Arriaga, E.A. “Simultaneous Laser-Induced Fluorescence and Scattering Detection of Individual Particles Separated by Capillary Electrophoresis”, Anal. Chem. 79, 5474-8 (2007).

74.  Meany, D.L.; Thompson, L.V.; Arriaga, E.A. “Simultaneously Monitoring the Superoxide in the Mitochondrial Matrix and Extramitochondrial Space by Micellar Electrokinetic Chromatography with Laser-Induced Fluorescence”, Anal. Chem. 79, 4588-94 (2007).

73.  Whiting, C.E.; Arriaga, E.A. “Evaluation of Individual Particle Capillary Electrophoresis Experiments via Quantile Analysis”, J. Chromatogr., A. 1157, 446-53 (2007).

72.  Li, D.; Xie, H.; Thompson, L.V.; Arriaga, E.A.; Griffin, T.J. “Identification of Carbonylated Proteins from Enriched Rat Skeletal Muscle Mitochondria Using Affinity Chromatography-Stable Isotope Labeling and Tandem Mass Spectrometry”, Proteomics 7, 1150-1163 (2007)

71.  Poe, B.G.; Navratil, M.; Arriaga, E.A. “Absolute Quantitation of a Heteroplasmic Mitochondrial DNA Deletion Using a Multiplex Three-Primer Real-Time PCR Assay,” Anal. Biochem. 362, 193-200 (2007).

70.  Johnson, R.D.; Navratil, M.; Poe, B.G.; Xiong, G.; Olson, K.J.; Ahmadzadeh, H.; Andreyev, D.; Duffy, C.F.; Arriaga, E.A. “Analysis of Mitochondria Isolated from Single Cells,” Anal. Bioanal. Chem. 387, 107-18 (2007).

69.  Ahmadzadeh, H.; Andreyev, D.; Arriaga, E. A.; Thompson, L.V. “Capillary Electrophoresis Reveals Changes in Individual Mitochondrial Particles Associated with Skeletal Muscle Fiber Type and Age,” J. Gerontol. Series A: Biol. Sci. Med. Sci. 61A, 1211-18 (2006).

68.  Forner, F.; Arriaga, E.A.; Mann, M. “Mild Protease Treatment as a Small-Scale Biochemical Method for Mitochondria Purification and Proteomic Mapping of Cytoplasm-Exposed Mitochondrial Proteins”, J. Proteome Res. 5, 3277-87 (2006).

67.  Poe, B.G.; Navratil, M.; Arriaga, E.A. “Analysis of Subcellular-Sized Particles: Capillary Electrophoresis with Post-Column Laser-Induced Fluorescence Detection versus Flow Cytometry,” J. Chromatogr., A. 1137, 249-55 (2006).

66.  Whiting, C.; Arriaga, E.A. “CE-LIF Analysis of Mitochondria Using Uncoated and Dynamically Coated Capillaries”, Electrophoresis 27, 4523-31 (2006).

65.  Eder, A.R.; Arriaga, E.A. “Capillary Electrophoresis Monitors Enhancement in Reactive Oxygen Species Production upon Treatment with Doxorubicin”, Chem. Res. Toxicol. 19, 1151-9 (2006).

64.  Meany, D.L.; Poe, B.G.; Navratil, M.; Moraes, C.T.; Arriaga, E.A. “Superoxide Released into the Mitochondrial Matrix”, Free Radical Biol. Med. 41, 950-9 (2006).

63.  Duffy, C. F.; MacCraith, B.; Diamond, D.; O'Kennedy, R.; Arriaga, E.A. “Fast Electrophoretic Analysis of Individual Mitochondria Using Microchip Capillary Electrophoresis with Laser Induced Fluorescence Detection,” Lab Chip 6, 1007-11 (2006). This article was chosen for inclusion in the Royal Society of Chemistry’s Chemical Biology Virtual Journal, Issue 15, 2006.

62.  Eder, A.R.; Chen, J.S.; Arriaga, E.A. “Separation of Doxorubicin and Doxorubicinol by Cyclodextrin-Modified Micellar Electrokinetic Capillary Chromatography”, Electrophoresis 27, 3263-70 (2006).

61.  Navratil, M.; Mabbott, G. A.; Arriaga, E.A. “Chemical Microscopy Applied to Biological Systems,” Review, Anal. Chem. 78, 4005-19 (2006).

60.  Chen, Y.; Arriaga, E.A. “Individual Acidic Organelle pH Measurements by Capillary Electrophoresis”, Anal. Chem. 78, 820-6 (2006).

59.  Ahmadzadeh, H.; Thompson, L.V.; Arriaga, E.A. “On-Column Labeling for Capillary Electrophoretic Analysis of Individ­ual Mitochondria Sampled from Tissue Cross Sections”, Technical Note, Anal. Bioanal. Chem. 384, 169-74 (2006).

58.  Eder, A. E.; Arriaga, E. A., “Micellar Electrokinetic Capillary Chromatography Reveals Differences in Intracellular Metabolism between Liposomal and Free Doxorubicin Treatment of Human Leukemia Cell Lines”, J. Chromatogr., B.: Anal. Technol. Biomed. Life Sci. 829, 115-22 (2005).

57.  Olson, K. J.; Ahmadzadeh, H.; Arriaga, E. A. “Within the Cell: Analytical Techniques for Subcellular Analysis”, Anal. Bioanal. Chem. 382, 906-17 (2005).

56.  Xiong, G.; Chen, Y.; Arriaga, E. A. "Measuring the Doxorubicin Content of Single Nuclei by Micellar Electrokinetic Capillary Chromatography with Laser-Induced Fluorescence Detection", Anal. Chem. 77, 3488-93 (2005).

55.  Chen, Y.; Walsh, R.; Arriaga, E. A. "Selective Determination of the Doxorubicin Content of Individual Acidic Organ­elles in Impure Subcellular Fractions", Accelerated Article, Anal. Chem. 77, 2281-7 (2005).

54.  Ahmadzadeh, H.; Dua, R.; Presley, A. D.; Arriaga, E. A. “Automated Analysis of Individual Particles Using a Commer­cial Capillary Electrophoresis System”, J. Chromatogr., A. 1064, 107-14 (2005).

53.  Anderson, A. B.; Xiong, G.; Arriaga, E. A. “Doxorubicin Accumulation in Individually Electrophoresed Organelles”, J. Am. Chem. Soc. 126, 9168-9 (2004).

52.  Gunasekera, N.; Lee, W. L.; Kim, S.; Musier-Forsyth, K.; Arriaga, E. A. “Nuclear Localization of Aminoacyl-tRNA Synthetases Using Single-Cell Capillary Electrophoresis Laser-Induced Fluorescence Analysis”, Anal. Chem. 76, 4741-6 (2004).

51.  Arriaga, E. A. Book review of Monolithic Materials: Preparation, Properties and Applications, Journal of Chromatogra­phy Library, Volume 67, F. Svec, T.B. Tennikova, and Z. Deyl, eds., Elsevier: Amsterdam, 2003, in J. Am. Chem. Soc. 126, 9874 (2004).

50.  Anderson, A. B.; Arriaga, E. A. “Subcellular Metabolite Profiles of the Parent CCRF-CEM and the Derived CEM/C2 Cell Lines after Treatment with Doxorubicin”, J. Chromatogr., B. 808, 295-302 (2004)

49.  Fuller, K.; Arriaga, E. A. "Capillary Electrophoresis Monitors Changes in the Electrophoretic Behavior of Mitochondrial Preparations", J. Chromatogr., B. 806, 151-9 (2004).

48.  Gunasekera, N.; Xiong, G.; Musier-Forsyth, K.; Arriaga, E. A. “A Capillary Electrophoretic Method For Monitoring the Presence of a-Tubulin in Nuclear Preparations”, Anal. Biochem. 330, 1-9 (2004).

47.  Ocvirk, G.; Salimi-Moosavi, H.; Szarka, R. J.; Arriaga, E. A.; Andersson, P. E.; Smith, R.; Dovichi, N. J.; Harrison D.J. “b-Galactosidase Assays of Single Cell Lysates on a Microchip: A Complementary Method for Enzymatic Analysis of Single Cells,” Proc. IEEE 92, 115-25 (2004).

46.  Gunasekera, N.; Olson, K. J.; Musier-Forsyth, K.; Arriaga, E. A. "Capillary Electrophoretic Separation of Nuclei Released from Single Cells", Anal. Chem. 76, 655-662 (2004).

45.  Ahmadzadeh, H.; Johnson, R. D.; Thompson, L.; Arriaga, E. A. "Direct Sampling from Muscle Cross Sections for Electrophoretic Analysis of Individual Mitochondria", Anal. Chem. 76, 315-321 (2004).

44.  Xiong, G.; Aras, O.; Shet, A.; Key, N.; Arriaga, E. A. "Analysis of Individual Platelet-Derived Microparticles, Comparing Flow Cytometry and Capillary Electrophoresis with Laser-Induced Fluorescence Detection", Analyst. 128, 581-588 (2003).

43.  Pinto, D.; Arriaga, E. A.; Schoenherr, R.M.; Chou, S. S.-H.; Dovichi, N. J. "Kinetics and Apparent Activation Energy of the Reaction of the Fluorogenic Reagent 5-Furoylquinoline-3-carboxaldehyde with Ovalbumin", J. Chromatogr., B 793, 107-114 (2003).

42.  Presley, A. D.; Fuller, K. M.; Arriaga, E. A. "MitoTracker Green Labeling of Mitochondrial Proteins and Their Subse­quent Analysis by Capillary Electrophoresis with Laser-Induced Fluorescence Detection", J. Chromatogr., B. 793, 141-150 (2003).

41.  Fuller, K.; Arriaga, E. A. "Analysis of Individual Acidic Organelles by Capillary Electrophoresis with Laser-Induced Fluorescence Detection Facilitated by the Endocytosis of Fluorescently Labeled Microspheres", Anal. Chem. 75, 2123-2130 (2003).

40.  Fuller, K.; Arriaga, E. A. “Advances in Single Mitochondria Analysis", Invited review, Curr. Opin. Biotechnol. 14, 35-41 (2003).

39.  Anderson, A. B.; Ciriacks, C. M.; Fuller, K. M.; Arriaga, E. A. "Distribution of Zeptomole-Abundant Doxorubicin Metabolites in Subcellular Fractions by Capillary Electrophoresis with Laser-induced Fluorescence Detection", Anal. Chem. 75, 8-15 (2003).

38.  Gunasekera, N.; Musier-Forsyth, K.; Arriaga, E. A. "Electrophoretic Behavior of Individual Nuclear Species as Deter­mined by Capillary Electrophoresis with Laser-induced Fluorescence Detection", Electrophoresis 23, 2110-16 (2002).

37.  Duffy, C. F.; McEathron, A.; Arriaga, E. A. "Determination of Individual Microsphere Properties by Capillary Electro­phoresis with Laser-Induced Fluorescence Detection", Electrophoresis 23, 2040-47 (2002).

36.  Fuller, K. M.; Duffy, C. F.; Arriaga, E. A. "Determination of the Cardiolipin Content of Individual Mitochondria by Capillary Electrophoresis with Laser-Induced Fluorescence Detection", Electrophoresis 23, 1571-76 (2002).

35.  Anderson, A.; Gergen, J.; Arriaga, E. A. "Detection of Doxorubicin and Metabolites in Cell Extracts and in Single Cells by Capillary Electrophoresis with Laser-Induced Fluorescence Detection". J. Chromatogr., B 769, 97-106 (2002).

34.  Duffy, C. F.; Fuller, K.; Malvey, M.; O’Kennedy, R.; Arriaga, E. A. "Determination of Electrophoretic Mobility Distributions through the Analysis of Individual Mitochondrial Events by Capillary Electrophoresis with Laser-Induced Fluorescence Detection", Anal. Chem. 74, 171-76 (2002).

33.  Boulat, O.; McLaren, D. G.; Arriaga, E. A.; Chen, D. D. Y. "Separation of Free Amino Acids in Human Plasma by Capillary Electrophoresis with Laser Induced Fluorescence: Potential for Emergency Diagnosis of Inborn Errors of Metabolism", J. Chromatogr., B: Biomed. Sci. Appl. 754, 217-28 (2001).

32.  Strack, A.; Duffy, C. F.; Malvey, M.; Arriaga, E. A. "Individual Mitochondrion Characterization: A Comparison of Classical Assays to Capillary Electrophoresis with Laser-Induced Fluorescence Detection", Anal. Biochem. 294, 141-7 (2001).

31.  Duffy, C. F.; Gafoor, S.; Richards, D. F.; Admadzadeh, H.; O’Kennedy, R.; Arriaga, E. A. "Determination of Proper­ties of Individual Liposomes by Capillary Electrophoresis with Post-Column Laser-Induced Fluorescence Detection", Anal. Chem. 73, 1855-61 (2001).

30.  Krylov, S. N.; Arriaga, E. A.; Chan, N. W. C.; Dovichi, N. J.; Palcic, M. M. "Metabolic Cytometry: Monitoring Oligo­saccharide Biosynthesis in Single cells by Capillary Electrophoresis", Anal. Biochem. 283 (2), 133-5 (2000).

29.  Krylov, S. N.; Arriaga, E. A.; Zhang, Z.; Chan, N. W. C.; Palcic, M. M; Dovichi, N. J. "Single-Cell Analysis Avoids Sample Processing Bias", J. Chromatogr., B: Biomed. Sci. Appl. 741, 31-5 (2000).

28.  Krylov, S. N.; Starke, D. A.; Arriaga, E. A.; Zhang, Z.; Chan, N. W. C.; Palcic, M. M., Dovichi, N. J. Technical Notes:  "Instrumentation for Chemical Cytometry", Anal. Chem. 72, 872-7 (2000).

27.  Zhang, Z.; Krylov, S.; Arriaga, E. A.; Polakowski, R; Dovichi, N. J. "One-Dimensional Protein Analysis of an HT29 Human Colon Adenocarcinoma Cell", Anal. Chem. 72, 318-22 (2000).

26.  Krylov, S. N.; Arriaga, E.; Chan, N.W.C.; Dovichi, N.; Palcic, M.M. "Metabolic Cytometry: Monitoring Oligosaccharide Biosynthesis in Single Cells" in Sialobiology and Other Novel Forms of Glycosylation. Y. Inoue, Y.C. Lee, and F.A. Troy II, Eds., Gakushin Publishing, Osaka, Japan, 259-64 (1999).

25.  Krylov, S. N.; Zhang, Z.; Chan, N. W. C.; Arriaga, E .A.; Palcic, M. M.; Dovichi, N. J. "Correlating Cell Cycle with Metabolism in Single Cells: Combination of Image and Metabolic Cytometry", Cytometry 37, 14-20 (1999).

24.  Le, X. C.; Tan, W.; Scaman, C. H.; Szpacenko, A.; Arriaga, E.; Zhang, Y.; Dovichi, N. J.; Hindsgaul, O.; Palcic, M. M. "Single Cell Studies of Enzymatic Hydrolysis of a Tetramethylrhodamine Labeled Triglucoside in Yeast", Glycobiology 9, 219-25 (1999).

23.  Ocvirk, G.; Salimi-Moosavi, H.; Szarka, R. J.; Arriaga, E. A.; Andersson, P. E.; Smith, R.; Dovichi, N. J.; Harrison, D. J. "Single Cell Enzymatic Analysis on a Microchip: Lysing of Single Cells and Identification of Their b-galactosidase Activity", Proceedings of Third Conference on Micro-total Analysis System, Banff, Alberta, Canada (1998).

22.  Craig, D. B.; Polakowski, R.; Wong, J. C. Y; Arriaga, E. A.; Ahmadzadeh, H.; Stathakis, C.; Dovichi, N. J. "SDS-Capillary Electrophoresis of Proteins in a Sieving Matrix Utilizing Two-Spectral Channel Laser-Induced Fluorescence Detection", Electrophoresis 19, 2175-78 (1998).

21.  Lee, I-H; Pinto, D.; Arriaga, E. A.; Dovichi, N. J. "Picomolar Analysis of Proteins Using Electrophoretically Mediated Microanalysis and Capillary Electrophoresis with Laser Induced Fluorescence Detection", Anal. Chem. 70, 4546-8 (1998).

20.  Stathakis, C.; Arriaga, E. A.; Dovichi, N. J. "Protein Profiling Employing Capillary Electrophoresis with Dendrimers as Pseudostationary Phase Media", J. Chromatogr., A 817, 233-8 (1998).

19.  Stathakis, C.; Arriaga, E. A.; Lewis, D. F.; Dovichi, N. J. "Cationic and Anionic Polymeric Additives for Wall Deactivation and Selectivity Control in the Capillary Electrophoretic Separation of Proteins in Food Samples", J. Chromatogr., A 817, 227-32 (1998).

18.  Craig, D. B.; Arriaga, E.; Wong, J. C. Y.; Lu, H.; Dovichi, N. J. News & Features"The Life and Death of a Single Enzyme Molecule", Anal. Chem. 70, 39A-43A (1998).

17.  Pinto, D. M.; Arriaga, E. A.; Craig, D.; Angelova, J.; Sharma, N.; Ahmadzadeh, H.; Dovichi, N. J. "Picomolar Assay of Native Proteins by Capillary Electrophoresis Precolumn Labeling, Submicellar Separation, and Laser-Induced Fluorescence Detection", Anal. Chem. 69, 3015-21 (1997).

16.  Craig, D. B.; Arriaga, E.; Wong, J. C. Y.; Lu, H.; Dovichi, N. J. "Studies on Single Alkaline Phosphatase Molecules: Reaction Rate and Activation Energy of a Reaction Catalyzed by a Single Molecule and the Effect of Thermal Denaturation--The Death of an Enzyme", J. Am. Chem. Soc. 118 (22), 5245 -53 (1996).

15.  Figeys, D.; Ahmadzadeh, H.; Arriaga, E.; Dovichi, N. J. "Pseudo-Coulometric Loading in Capillary Electro­phoresis DNA Sequencing",  J. Chromatogr., A 744, 325-31 (1996).

14.  Zhang, Y.; Arriaga, E.; Diedrich, P.; Hindsgaul, O.; Dovichi, N.J. "Nanomolar Determination of Aminated Sugars by Capillary Electrophoresis", J. Chromatogr., A 716, 221-29 (1995).

13.  Pinto, D. M.; Arriaga, E. A.; Sia, S.; Li, Z.; Dovichi, N. J. "Solid-Phase Fluorescent Labeling Reaction of Picomole Amounts of Insulin in Very Dilute Solutions and Their Analysis by Capillary Electrophoresis", Electrophoresis 16, 534-40 (1995).

12.  Craig, D.; Arriaga, E.; Banks, P.; Zhang, Y.; Renborg, A.; Palcic, M. M.; Dovichi, N. J. "Fluorescently-Based Enzymatic Assay by Capillary Electrophoresis Laser-Induced Fluorescence Detection for the Determination of a Few B-Galactosidase Molecules", Anal. Biochem. 226, 147-53 (1995).

11.  Arriaga, E. A.; Zhang, Y.; Dovichi, N. J. "Use of 3-(P-carboxybenzoyl)-quinoline-2-carboxaldehyde (CBQ) to Label Amino Acids for High Sensitivity Fluorescence Detection in Capillary Electrophoresis", Anal. Chim. Acta 299, 319-26 (1995).

10.  Tarr, M.; Arriaga, E.; Valenzeno, D. "Progression of Cardiac Potassium Current Modification after Brief Exposure to Reactive Oxygen", J. Mol. Cell. Cardiol. 27(5), 1099-109 (1995).

9.     Lu, H.; Arriaga, E.; Chen, D. Y.; Figeys, D.; Dovichi, N. J. "The Activation Energy of Single-Stranded DNA Moving through Cross-Linked Polyacrylamide Gels at 300 V/Cm:  Effect of Temperature on Sequencing Rate in High-Electric-Field Capillary Gel Electrophoresis", J. Chromatogr., A 680, 503-10 (1994).

8.     Lu, H.; Arriaga, E.; Chen, D. Y.; Starke, H.; Dovichi, N. J. "High-Speed and High-Accuracy DNA Sequencing by Capillary Gel Electrophoresis in a Simple, Low Cost Instrument: Two-Color Peak-Height Encoded Sequencing at 40o C", J.Chromatogr. A 680, 497-501 (1994).

7.     Figeys, D.; Arriaga, E.; Renborg, A.; Dovichi, N. J. "Use of the Fluorescent Intercalating Dyes POPO-3, YOYO-3 and YOYO-1 for Ultrasensitive Detection of Double-Stranded DNA Separated by Capillary Electrophoresis with Hydroxypropylmethyl Cellulose and Non-Cross-Linked Polyacrylamide", J. Chromatogr., A 669, 205-16 (1994).

6.     Best, N.; Arriaga, E.; Chen, D. Y.; Dovichi, N. J."Separation of Fragments up to 570 Bases in Length by Use of 6% T Non-Cross-Linked Polyacrylamide for DNA Sequencing in Capillary Electrophoresis", Anal. Chem. 66(22), 4063-7 (1994).

5.     Arriaga, E.; Frolov, A.; Tarr, M.; Valenzeno, D. P. "Membrane Ionic Current Photomodification by Rose Bengal and Menadione: Role of Singlet Oxygen", Photochem. Photobiol. 59(6), 637-42 (1994).

4.     Tarr, M.; Arriaga E.; Goertz, K. K.; Valenzeno, D. P. "Properties of Cardiac ILeak Induced by Photosensi­tizer-Generated Reactive Oxygen", Free Radical Biol. Med. 16(4), 477-84 (1994).

3.     Arriaga, E.; Chen, D. Y.; Cheng, X. L.; Dovichi, N. J. "High Efficiency Filter Fluorometer for Capillary Elec­trophoresis and Its Application to Fluorescein Thiocarbamyl Amino Acids", J. Chromatogr., A 652, 347-53 (1993).

2.     Valenzeno, D. P.; Arriaga, E.; Trank, J.; Tarr, M. "Membrane Potential Can Influence the Rate of Membrane Photomodification", Photochem. Photobiol. 57, 996-9 (1993).

1.     Arriaga, E. A.; Stephens, R. "Detection of Structured Interferences in a.c. Zeeman Atomic Absorption by Harmonic Analysis", Spectrochim. Acta 44B, 867-76 (1989).