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Our research efforts combine expertise in bioanalytical chemistry, chemical biology, and biomedical engineering. We develop unique methods and instrumentation to characterize the chemical, biochemical, and physiological properties of single biological cells and their subcellular components (organelles). These resources enable single cell and subcellular studies that are essential to investigate biological complexity, which presently sets limitations to the research carried out in the biomedical and biotechnological fields. Within these fields we strive to help answers key questions related to the aging process, diabetes and obesity and neurodegeneration as we apply our developments to biological models including mammalian cell cultures, murine and human skeletal muscle, and Caenorhabditis elegans.